5'-deoxy-5'-methylthioadenosine phosphorylase: Difference between revisions
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== Function == | == Function == | ||
'''5’-deoxy-5’-methylthioadenosine phosphorylase''' (MTAP) catalyzes the reversible phosphorolysis of <scene name='59/595220/Cv/2'>5’-deoxy-5’-methylthioadenosine (MTA)</scene> to adenine and 5-methylthio-D-ribose-1-phosphate. <scene name='59/595220/Cv/ | '''5’-deoxy-5’-methylthioadenosine phosphorylase''' (MTAP) catalyzes the reversible phosphorolysis of <scene name='59/595220/Cv/2'>5’-deoxy-5’-methylthioadenosine (MTA)</scene> to adenine and 5-methylthio-D-ribose-1-phosphate. <scene name='59/595220/Cv/4'>Click here to see active site</scene>. MTAP is part of the polyamine metabolism. This reaction is the principle source of adenine in human cells. MTAP catalyzes the first step in the methionine salvage pathway.<ref>PMID:10404592</ref> | ||
== Disease == | == Disease == | ||