Sandbox 420: Difference between revisions
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==Regulation of Neurotransmitters== | ==Regulation of Neurotransmitters== | ||
The highest concentration of CB1 receptors is found within presynaptic nerve terminals | The highest concentration of CB1 receptors is found within presynaptic nerve terminals <ref>PMID: 16723537</ref>. When ligands bind to CB1 receptors in presynaptic nerve terminals, calcium channels are inhibited. The release of calcium is a key component of nerve signal transduction pathway that results in the release of neurotransmitters in the synaptic cleft. As a result, activated CB1 receptors are able to regulate the release of neurotransmitters. CB1 receptors have been shown to inhibit the release of glutamate, acetylcholine, and noradrenaline <ref name = "review"/>. | ||
Additionally, activated CB1 receptors suppresses the activity of GABAergic neurons, which control neurons responsible for the release of dopamine (7). By suppressing GABAergic neurons, dopamine levels in the brain are increased. This action of CB1 receptors is responsible for the pleasure associated the THC use and the potential for abuse of exergonic cannabinoids. | Additionally, activated CB1 receptors suppresses the activity of GABAergic neurons, which control neurons responsible for the release of dopamine (7). By suppressing GABAergic neurons, dopamine levels in the brain are increased. This action of CB1 receptors is responsible for the pleasure associated the THC use and the potential for abuse of exergonic cannabinoids. | ||