Aminoacyl tRNA Synthetase: Difference between revisions
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'''Aminoacyl tRNA synthetase''' (aaRS) catalyzes the esterification of a specific amino acid to its cognate tRNA to form an aminoacyl-tRNA. The amino acid is transferred by the ribosome from the aminoacylated-tRNA onto a growing polypeptide chain. Class I of aaRS is a monomer or dimer, it has 2 highly conserved sequence motifs and it aminoacylates at the 2’-OH of an adenosine nucleotide. Class II of aaRS is a dimer or tetramer, it has 3 highly conserved sequence motifs and it aminoacylates at the 3’-OH of an adenosine nucleotide. CP1 domain of RS edits a mischarged aa-tRNA. Some of the crystal structures are complexes of the RS with their reactant analog: amino acid-sulfamoyl adenine (aa-SA). For '''pyrrolysyl-RS''' details see [[Pyrrolysyl-tRNA synthetase]]. | '''Aminoacyl tRNA synthetase''' (aaRS) catalyzes the esterification of a specific amino acid to its cognate tRNA to form an aminoacyl-tRNA. The amino acid is transferred by the ribosome from the aminoacylated-tRNA onto a growing polypeptide chain. Class I of aaRS is a monomer or dimer, it has 2 highly conserved sequence motifs and it aminoacylates at the 2’-OH of an adenosine nucleotide. Class II of aaRS is a dimer or tetramer, it has 3 highly conserved sequence motifs and it aminoacylates at the 3’-OH of an adenosine nucleotide. CP1 domain of RS edits a mischarged aa-tRNA. Some of the crystal structures are complexes of the RS with their reactant analog: amino acid-sulfamoyl adenine (aa-SA).<ref>PMID:8422978</ref> For '''pyrrolysyl-RS''' details see [[Pyrrolysyl-tRNA synthetase]]. | ||
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**[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br /> | **[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br /> | ||
**[[2lgs]] – StGlnRS + Glu<br /> | **[[2lgs]] – StGlnRS + Glu<br /> | ||
**[1qrt]], [[1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br /> | **[[1qrt]], [[1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br /> | ||
**[[1gtr]], [[1gts]], [[1gsg]] - EcGlnRS + Gln-tRNA<br /> | **[[1gtr]], [[1gts]], [[1gsg]] - EcGlnRS + Gln-tRNA<br /> | ||
**[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog | **[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog | ||
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== References == | == References == | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||