5dsv: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human proteasome alpha7 tetradecamer==
 
<StructureSection load='5dsv' size='340' side='right' caption='[[5dsv]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
The entry 5dsv is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5dsv]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DSV FirstGlance]. <br>
Authors: Satoh, T., Thammaporn, R., Seetaha, S., Kato, K.
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsv OCA], [http://pdbe.org/5dsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsv RCSB], [http://www.ebi.ac.uk/pdbsum/5dsv PDBsum]</span></td></tr>
Description:
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Thammaporn, R]]
[[http://www.uniprot.org/uniprot/PSA3_HUMAN PSA3_HUMAN]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.<ref>PMID:11350925</ref> <ref>PMID:17499743</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Proteasome endopeptidase complex]]
[[Category: Kato, K]]
[[Category: Satoh, T]]
[[Category: Satoh, T]]
[[Category: Kato, K]]
[[Category: Seetaha, S]]
[[Category: Seetaha, S]]
[[Category: Thammaporn, R]]
[[Category: Hydrolase]]
[[Category: Proteasome]]

Revision as of 19:17, 2 December 2015

Crystal structure of human proteasome alpha7 tetradecamerCrystal structure of human proteasome alpha7 tetradecamer

Structural highlights

5dsv is a 14 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Proteasome endopeptidase complex, with EC number 3.4.25.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[PSA3_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.[1] [2]

References

  1. ↑ Touitou R, Richardson J, Bose S, Nakanishi M, Rivett J, Allday MJ. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J. 2001 May 15;20(10):2367-75. PMID:11350925 doi:http://dx.doi.org/10.1093/emboj/20.10.2367
  2. ↑ Sasaki M, Sukegawa J, Miyosawa K, Yanagisawa T, Ohkubo S, Nakahata N. Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes. Prostaglandins Other Lipid Mediat. 2007 Jun;83(4):237-49. Epub 2006 Dec 27. PMID:17499743 doi:http://dx.doi.org/10.1016/j.prostaglandins.2006.12.001

5dsv, resolution 3.75Å

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