5e6p: Difference between revisions

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'''Unreleased structure'''
==PlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complex==
 
<StructureSection load='5e6p' size='340' side='right' caption='[[5e6p]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
The entry 5e6p is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5e6p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E6P FirstGlance]. <br>
Authors: Pascoe, H.G., Zhang, X.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6p OCA], [http://pdbe.org/5e6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e6p RCSB], [http://www.ebi.ac.uk/pdbsum/5e6p PDBsum]</span></td></tr>
 
</table>
Description:  
== Function ==
[[Category: Unreleased Structures]]
[[http://www.uniprot.org/uniprot/PLXB2_MOUSE PLXB2_MOUSE]] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro).<ref>PMID:17554007</ref> <ref>PMID:19948886</ref> <ref>PMID:21122816</ref> <ref>PMID:21966369</ref>  [[http://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Pascoe, H G]]
[[Category: Zhang, X]]
[[Category: Zhang, X]]
[[Category: Pascoe, H.G]]
[[Category: Complex]]
[[Category: Pdz]]
[[Category: Pdz-rhogef]]
[[Category: Plexin]]
[[Category: Signaling protein]]

Revision as of 22:01, 1 December 2015

PlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complexPlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complex

Structural highlights

5e6p is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[PLXB2_MOUSE] Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro).[1] [2] [3] [4] [ARHGB_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.

References

  1. ↑ Deng S, Hirschberg A, Worzfeld T, Penachioni JY, Korostylev A, Swiercz JM, Vodrazka P, Mauti O, Stoeckli ET, Tamagnone L, Offermanns S, Kuner R. Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J Neurosci. 2007 Jun 6;27(23):6333-47. PMID:17554007 doi:http://dx.doi.org/10.1523/JNEUROSCI.5381-06.2007
  2. ↑ Hirschberg A, Deng S, Korostylev A, Paldy E, Costa MR, Worzfeld T, Vodrazka P, Wizenmann A, Gotz M, Offermanns S, Kuner R. Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis. Mol Cell Biol. 2010 Feb;30(3):764-80. doi: 10.1128/MCB.01458-09. Epub 2009 Nov, 30. PMID:19948886 doi:http://dx.doi.org/10.1128/MCB.01458-09
  3. ↑ Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH. Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development. Mol Cell Neurosci. 2011 Feb;46(2):419-31. doi: 10.1016/j.mcn.2010.11.005. Epub, 2010 Nov 29. PMID:21122816 doi:http://dx.doi.org/10.1016/j.mcn.2010.11.005
  4. ↑ Roney KE, O'Connor BP, Wen H, Holl EK, Guthrie EH, Davis BK, Jones SW, Jha S, Sharek L, Garcia-Mata R, Bear JE, Ting JP. Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. PLoS One. 2011;6(9):e24795. doi: 10.1371/journal.pone.0024795. Epub 2011 Sep 23. PMID:21966369 doi:http://dx.doi.org/10.1371/journal.pone.0024795

5e6p, resolution 3.21Å

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