4rmq: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of the D59N Beta-2 Microglobulin mutant==
+<StructureSection load='4rmq' size='340' side='right' caption='[[4rmq]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
-The entry 4rmq is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rmq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RMQ FirstGlance]. <br>
-Authors: de Rosa, M., Bolognesi, M., Ricagno, S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yxf|2yxf]], [[4fxl|4fxl]], [[4rmr|4rmr]], [[4rms|4rms]], [[4rmt|4rmt]], [[4rmu|4rmu]], [[4rmv|4rmv]], [[4rmw|4rmw]]</td></tr>
-Description: Crystal structure of the D59N Beta-2 Microglobulin mutant
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmq OCA], [http://pdbe.org/4rmq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rmq RCSB], [http://www.ebi.ac.uk/pdbsum/4rmq PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bolognesi, M]]
 [[Category: Ricagno, S]]
-[[Category: De Rosa, M]]
+[[Category: Rosa, M de]]
-[[Category: Bolognesi, M]]
+[[Category: Amyloidosis]]
+[[Category: Beta-sandwitch]]
+[[Category: Genetic disease]]
+[[Category: Immune system]]
+[[Category: Immunoglobin]]
+[[Category: Mhc class i]]
+[[Category: Pathologic mutation]]