5e7v: Difference between revisions

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'''Unreleased structure'''
==Potent Vitamin D Receptor Agonist==
 
<StructureSection load='5e7v' size='340' side='right' caption='[[5e7v]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
The entry 5e7v is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5e7v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E7V FirstGlance]. <br>
Authors: Otero, R., Seoane, S., Sigueiro, R., Belorusova, A.Y., Maestro, M.A., Perez-Fernandez,R., Rochel, N., Mourino, A.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7E:1-ALPHA-HYDROXY-27-NOR-25-O-CARBONYL-VITAMIN+D3'>M7E</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e7v OCA], [http://pdbe.org/5e7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e7v RCSB], [http://www.ebi.ac.uk/pdbsum/5e7v PDBsum]</span></td></tr>
Description: Potent Vitamin D Receptor Agonist
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Perez-Fernandez,R]]
[[http://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Belorusova, A Y]]
[[Category: Maestro, M A]]
[[Category: Mourino, A]]
[[Category: Mourino, A]]
[[Category: Otero, R]]
[[Category: Perez-Fernandez, R]]
[[Category: Rochel, N]]
[[Category: Seoane, S]]
[[Category: Seoane, S]]
[[Category: Maestro, M.A]]
[[Category: Otero, R]]
[[Category: Sigueiro, R]]
[[Category: Sigueiro, R]]
[[Category: Belorusova, A.Y]]
[[Category: Ligand binding domain]]
[[Category: Rochel, N]]
[[Category: Transcription]]
[[Category: Vdr]]
[[Category: Vitamin d nuclear receptor]]

Revision as of 07:46, 1 December 2015

Potent Vitamin D Receptor AgonistPotent Vitamin D Receptor Agonist

Structural highlights

5e7v is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.[1]

References

  1. ↑ Ciesielski F, Rochel N, Moras D. Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092 doi:http://dx.doi.org/10.1016/j.jsbmb.2006.12.003

5e7v, resolution 2.40Å

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