1a6a: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6a OCA], [http://www.ebi.ac.uk/pdbsum/1a6a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6a RCSB]</span> | |||
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[[Category: Mellins, E.]] | [[Category: Mellins, E.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
[[Category: complex (transmembrane/glycoprotein)]] | [[Category: complex (transmembrane/glycoprotein)]] | ||
[[Category: mhc glycoprotein]] | [[Category: mhc glycoprotein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:14 2008'' | ||
Revision as of 18:34, 30 March 2008
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| , resolution 2.75Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3
OverviewOverview
A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.
About this StructureAbout this Structure
1A6A is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3., Ghosh P, Amaya M, Mellins E, Wiley DC, Nature. 1995 Nov 30;378(6556):457-62. PMID:7477400
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