CD44: Difference between revisions

Revision as of 15:49, 24 November 2015

Structure of mouse CD44 hyaluronan-binding domain complex with hyaluronic acid (PDB entry 2jcq)

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FunctionFunction

CD44 is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.^[1]

(2jcq).^[2]

RelevanceRelevance

CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.

3D structures of CD443D structures of CD44

Updated on 24-November-2015

1uuh, 4pz4 – hCD44 hyaluronan-binding domain – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
2jcp - mCD44 hyaluronan-binding domain – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, 4np3 - mCD44 hyaluronan-binding domain + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1]

[2]

@@ Line 1: / Line 1: @@
-<Structure load='2jcq' size='450' frame='true' align='right' caption='Structure of mouse CD44 hyaluronan-binding domain complex with 8-mer HA (PDB entry [[2jcq]])' scene='52/523368/Cv/1' />
+<Structure load='2jcq' size='450' frame='true' align='right' caption='Structure of mouse CD44 hyaluronan-binding domain complex with hyaluronic acid (PDB entry [[2jcq]])' scene='52/523368/Cv/1' />
 == Function ==
-'''CD44''' is a glycoprotein involved in cell-cell interactions.  CD44 is a receptor of hyaluronic acid (HA).  CD44 undergoes post-translational modification.  Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.
+'''CD44''' is a glycoprotein involved in cell-cell interactions.  CD44 is a receptor of hyaluronic acid (HA).  CD44 undergoes post-translational modification.  Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:17293874</ref>
-*<scene name='52/523368/Cv/2'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).
+*<scene name='52/523368/Cv/2'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref>
 == Relevance ==