2qqc: Difference between revisions

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New page: left|200px {{Structure |PDB= 2qqc |SIZE=350|CAPTION= <scene name='initialview01'>2qqc</scene>, resolution 2.00Å |SITE= <scene name='pdbsite=AC1:Ag2+Binding+Site+...
 
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|PDB= 2qqc |SIZE=350|CAPTION= <scene name='initialview01'>2qqc</scene>, resolution 2.00&Aring;
|PDB= 2qqc |SIZE=350|CAPTION= <scene name='initialview01'>2qqc</scene>, resolution 2.00&Aring;
|SITE= <scene name='pdbsite=AC1:Ag2+Binding+Site+For+Residue+A+671'>AC1</scene>, <scene name='pdbsite=AC2:Ag2+Binding+Site+For+Residue+E+671'>AC2</scene>, <scene name='pdbsite=AC3:Ag2+Binding+Site+For+Residue+A+672'>AC3</scene>, <scene name='pdbsite=AC4:Ag2+Binding+Site+For+Residue+K+671'>AC4</scene>, <scene name='pdbsite=AC5:Ag2+Binding+Site+For+Residue+I+671'>AC5</scene>, <scene name='pdbsite=AC6:Ag2+Binding+Site+For+Residue+I+672'>AC6</scene>, <scene name='pdbsite=AC7:Pyr+Binding+Site+For+Residue+B+53'>AC7</scene>, <scene name='pdbsite=AC8:Pyr+Binding+Site+For+Residue+D+53'>AC8</scene>, <scene name='pdbsite=AC9:Pyr+Binding+Site+For+Residue+F+53'>AC9</scene>, <scene name='pdbsite=BC1:Pyr+Binding+Site+For+Residue+H+53'>BC1</scene>, <scene name='pdbsite=BC2:Pyr+Binding+Site+For+Residue+J+53'>BC2</scene>, <scene name='pdbsite=BC3:Pyr+Binding+Site+For+Residue+L+53'>BC3</scene>, <scene name='pdbsite=BC4:Mpd+Binding+Site+For+Residue+C+700'>BC4</scene>, <scene name='pdbsite=BC5:Mpd+Binding+Site+For+Residue+E+700'>BC5</scene>, <scene name='pdbsite=BC6:Mpd+Binding+Site+For+Residue+B+700'>BC6</scene> and <scene name='pdbsite=BC7:Mpd+Binding+Site+For+Residue+I+700'>BC7</scene>
|SITE= <scene name='pdbsite=AC1:Ag2+Binding+Site+For+Residue+A+671'>AC1</scene>, <scene name='pdbsite=AC2:Ag2+Binding+Site+For+Residue+E+671'>AC2</scene>, <scene name='pdbsite=AC3:Ag2+Binding+Site+For+Residue+A+672'>AC3</scene>, <scene name='pdbsite=AC4:Ag2+Binding+Site+For+Residue+K+671'>AC4</scene>, <scene name='pdbsite=AC5:Ag2+Binding+Site+For+Residue+I+671'>AC5</scene>, <scene name='pdbsite=AC6:Ag2+Binding+Site+For+Residue+I+672'>AC6</scene>, <scene name='pdbsite=AC7:Pyr+Binding+Site+For+Residue+B+53'>AC7</scene>, <scene name='pdbsite=AC8:Pyr+Binding+Site+For+Residue+D+53'>AC8</scene>, <scene name='pdbsite=AC9:Pyr+Binding+Site+For+Residue+F+53'>AC9</scene>, <scene name='pdbsite=BC1:Pyr+Binding+Site+For+Residue+H+53'>BC1</scene>, <scene name='pdbsite=BC2:Pyr+Binding+Site+For+Residue+J+53'>BC2</scene>, <scene name='pdbsite=BC3:Pyr+Binding+Site+For+Residue+L+53'>BC3</scene>, <scene name='pdbsite=BC4:Mpd+Binding+Site+For+Residue+C+700'>BC4</scene>, <scene name='pdbsite=BC5:Mpd+Binding+Site+For+Residue+E+700'>BC5</scene>, <scene name='pdbsite=BC6:Mpd+Binding+Site+For+Residue+B+700'>BC6</scene> and <scene name='pdbsite=BC7:Mpd+Binding+Site+For+Residue+I+700'>BC7</scene>
|LIGAND= <scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
|LIGAND= <scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Arginine_decarboxylase Arginine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.19 4.1.1.19]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginine_decarboxylase Arginine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.19 4.1.1.19] </span>
|GENE= pdaD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
|GENE= pdaD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1945 COG1945], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK01285 PRK01285]</span>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qqc OCA], [http://www.ebi.ac.uk/pdbsum/2qqc PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2qqc RCSB]</span>
}}
}}


'''E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii'''
'''E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii'''


==Overview==
Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.


==About this Structure==
==About this Structure==
2QQC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQC OCA].  
2QQC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQC OCA].  
==Reference==
Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084067 18084067]
[[Category: Arginine decarboxylase]]
[[Category: Arginine decarboxylase]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]
[[Category: Soriano, E S.]]
[[Category: Soriano, E S.]]
[[Category: AG2]]
[[Category: MPD]]
[[Category: PYR]]
[[Category: arginine decarboxylase]]
[[Category: arginine decarboxylase]]
[[Category: autoprocessing]]
[[Category: autoprocessing]]
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[[Category: serinolysis]]
[[Category: serinolysis]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:28:27 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:02:37 2008''

Revision as of 11:02, 26 March 2008

File:2qqc.jpg


PDB ID 2qqc

Drag the structure with the mouse to rotate
, resolution 2.00Å
Sites: , , , , , , , , , , , , , , and
Ligands: , ,
Gene: pdaD (Methanocaldococcus jannaschii)
Activity: Arginine decarboxylase, with EC number 4.1.1.19
Domains: COG1945, PRK01285
Resources: FirstGlance, OCA, PDBsum, JenaLib, RCSB
Coordinates: save as pdb, mmCIF, xml



E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii


About this StructureAbout this Structure

2QQC is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Mar 26 10:02:37 2008

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