CD3: Difference between revisions
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'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.<ref>PMID:24488493</ref> | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.<ref>PMID:24488493</ref> | ||
*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain | *<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).<ref>PMID:15136729</ref> | ||
</StructureSection> | </StructureSection> | ||