Cadherin

Function Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental). The CDH superfamily contains: *Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts. Desmogleins (Des-CDH) are CDH found in desmosomes. Structural highlights The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by 2 Trp residues docking into the hydrophobic pocket of the neighboring CDH molecule.

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3D Structures of Cadherin3D Structures of Cadherin

Updated on 17-November-2015

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• CDH1
  • 1q1p – mCDH1 - mouse
    
  • 3q2v – mCDH1 ectodomain
    
  • 3qrb – mCDH1+2
• CDH5
  • 2koh – mCDH5+PAR3-PDZ3
    
• CDH6
  • 3lnd – mCDH6 EC12 (mutant)
    
• CDH8
  • 1zxk – mCDH8 EC1
    
  • 2a62 - mCDH8 EC1+EC2+EC3
    
• CDH11
  • 2a4c, 2a4e – mCDH11 EC1
    
• CDH20
  • 1zvn – cCDH20 EC1 – chicken
    
• CDH23
  • 3mvs, 2whv – mCDH23 N-terminal
    
  • 2kbr – hCDH23 peptide+harmonin – NMR - human
    
  • 2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
    
  • 2wbx – mCDH23 EC1
    
  • 2wcp - mCDH23 EC2
    
  • 2wd0 - mCDH23 EC1+EC2 (mutant)
    
  • 4apx, 4aq8, 4axw - mCDH23 EC1+EC2 + Prot-CDH15
    
  • 4aqa, 4aqe - mCDH23 EC1+EC2 (mutant) + Prot-CDH15
• C-CDH “classical”
  • 1l3w – XlC-CDH ectodomain - Xenopus laevis
    
  • 1q5b, 1q5c, 1q55, 1q5a – C-CDH model into desmosome – electron tomography
    
• E-CDH epithelial
  • 1edh - mE-CDH EC1+EC2+Ca
    
  • 3q2l, 3q2n - mE-CDH EC1+EC2 (mutant)
    
  • 1suh – mE-CDH N-terminal - NMR
    
  • 3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin
    
  • 3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)
    
  • 2qvf – mE-CDH1 CDH2
    
  • 4qd2 – mE-CDH + botulinum neurotoxin
    
  • 3ifq – hE-CDH EC1+EC2+EC3
    
  • 2o72 - hE-CDH EC1+EC2
    
  • 3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor
    
  • 2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
    
  • 1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes
    
• T-CDH membrane bound
  • 3k5r – mT-CDH EC1+EC2
    
  • 3k5s - cT-CDH EC1+EC2
    
  • 3k6d - XlT-CDH EC1
    
  • 3k6f - mT-CDH EC1
    
  • 3k6i - cT-CDH EC1
    
  • 2v37 – hT-CDH N-terminal - NMR
    
• N-CDH neuronal
  • 1nch, 1nci – mN-CDH
    
  • 1ncg – mN-CDH (mutant)
    
  • 2qvi, 4nuq – mN-CDH EC1-EC2
    
  • 4num, 4nup – mN-CDH EC1-EC2 (mutant)
    
  • 1ncj – mN-CDH two domains
    
  • 3q2w – mN-CDH ectodomain
    
  • 1op4 - mN-CDH prodomain - NMR
    
  • 3ubf – DmN-CDH ectodomain – Drosophila melanogaster
    
  • 3ubh - DmN-CDH EC1-4
    
  • 3ubg - DmN-CDH EC1-3
• P-CDH placental
  • 4nqq – mP-CDH EC1+EC2
    
• VE-CDH vascular epithelial
  • 3ppe – cVE-CDH EC1+EC2
    
• Protocadherin
  • 2yst – hProt-CDH7 EC3 – NMR
    
  • 2ee0 - hProt-CDH9 Ca domain – NMR
    
  • 1wyj - mProt-CDH β 14 - NMR
    
  • 1wuz - mProt-CDH4 EC1 – NMR
• Desmoglein
  • 2yqg – hDes-CDH EC1