Calcium/Calmodulin-dependent protein kinase: Difference between revisions

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== Structural highlights ==
== Structural highlights ==


CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD).  DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file).
CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD).  DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>


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==References==
==References==
 
<references/>
See [[Calcium-dependent protein kinase]]
See [[Calcium-dependent protein kinase]]

Revision as of 16:11, 17 November 2015

Function

Ca2+/Calmodulin dependent protein kinase (CaMK) are activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr.

  • CaMKI is a specialized CaM kinase.
  • CaMKII is multifunctional kinase.
  • CaMKIII phosphorylates eukaryotic elongation factor 2.
  • CASK is a membrane associated CaMK.
  • DAPK is a death-associated CaMK which protects cells from some programmed cell death.

For details see Calcium-dependent protein kinase.

Structural highlights

CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of and Thr 305 (T305 is not in the pdb file). [1]


Human CamKII subunit α kinase domain complex with indirubin (PDB code 2vz6)

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3D Structures of Ca2+/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase

Updated on 17-November-2015

ReferencesReferences

  1. ↑ Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654 doi:10.1371/journal.pbio.1000426

See Calcium-dependent protein kinase

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