Butyrylcholinesterase: Difference between revisions
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<StructureSection load='1p0m' size='450' side='right' scene='39/399020/Cv/ | <StructureSection load='1p0m' size='450' side='right' scene='39/399020/Cv/3' caption='Glycosylated human butyrylcholinesterase complex with choline, glycerol, sulfate and Cl- ions (PDB code [[1p0m]])'> | ||
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== Structural highlights == | == Structural highlights == | ||
Like in the AChE structure, BChE active site is located at the bottom of a ca. 20A deep gorge. The active site of BChE is similar to that of AChE. The differences are noticed in the lining of the gorge were some of the aromatic residues in AChE are substituted by hydrophobic ones and in the active site acyl-binding pocket where 2 Phe residues are replaced by Leu and Val in BChE. | Like in the AChE structure, BChE active site is located at the bottom of a ca. 20A deep gorge. The <scene name='39/399020/Cv/4'>active site of BChE</scene> is similar to that of AChE. The differences are noticed in the lining of the gorge were some of the aromatic residues in AChE are substituted by hydrophobic ones and in the active site acyl-binding pocket where 2 Phe residues are replaced by Leu and Val in BChE. | ||
</StructureSection> | </StructureSection> | ||