Sandbox 4465: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Gerardo Alvarez, Se Chang, Aiola Pandeli Stoja, Eunhwa Chun

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 ==Calmodulin==
 <StructureSection load='2bcx' size='340' side='right' caption='Homo sapien calmodulin showing Ca+2' scene=''>
-Calcium is an essential mineral that is needed in the human diet for proper functioning of neurons to strong bones and can also act as a second messenger for enzymes and proteins. Calmodulin (CaM), short for calcium modulated protein, is a small calcium binding protein with a three dimensional structure. Calmodulin has been known to be involved in various Ca2+ - dependent signal transduction pathways, can act as a Ca2+ sensor, and has been involved with regulated protein-kinases. Its’ importance can be exemplified by the fact that the protein has been known to be highly conserved in eukaryotes. Highly conserved structures that do not undergo significant evolutionary changes imply that the structure is mandatory for cell or organism survival and that any mutations in the genetic sequence that codes for the protein would be deleterious. The function of calmodulin is typically studied using yeast as a model organism. This is done for a variety of reasons, including the fact that yeast has a fully annotated genome with human homologues for genes associated with their ion channels, yeast is fast
+Calcium is an essential mineral that is needed in the human diet for proper functioning of neurons to strong bones and can also act as a second messenger for enzymes and proteins. Calmodulin (CaM), short for calcium modulated protein, is a small calcium binding protein with a three dimensional structure. Calmodulin has been known to be involved in various Ca2+ - dependent signal transduction pathways, can act as a Ca2+ sensor, and has been involved with regulated protein-kinases.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
+Its’ importance can be exemplified by the fact that the protein has been known to be highly conserved in eukaryotes. Highly conserved structures that do not undergo significant evolutionary changes imply that the structure is mandatory for cell or organism survival and that any mutations in the genetic sequence that codes for the protein would be deleterious. The function of calmodulin is typically studied using yeast as a model organism. This is done for a variety of reasons, including the fact that yeast has a fully annotated genome with human homologues for genes associated with their ion channels, yeast is fast
 == Calmodulin in the body ==