1mc0: Difference between revisions
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{{Structure | {{Structure | ||
|PDB= 1mc0 |SIZE=350|CAPTION= <scene name='initialview01'>1mc0</scene>, resolution 2.86Å | |PDB= 1mc0 |SIZE=350|CAPTION= <scene name='initialview01'>1mc0</scene>, resolution 2.86Å | ||
|SITE= | |SITE= <scene name='pdbsite=AC1:Pcg+Binding+Site+For+Residue+A+160'>AC1</scene> | ||
|LIGAND= <scene name='pdbligand=PCG:CYCLIC GUANOSINE MONOPHOSPHATE'>PCG</scene> | |LIGAND= <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span> | ||
|GENE= PDE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= PDE2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00065 GAF]</span> | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mc0 OCA], [http://www.ebi.ac.uk/pdbsum/1mc0 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1mc0 RCSB]</span> | |||
}} | }} | ||
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[[Category: Turley, S.]] | [[Category: Turley, S.]] | ||
[[Category: Wu, A.]] | [[Category: Wu, A.]] | ||
[[Category: | [[Category: 3',5'-cyclic nucleotide phosphodiesterase]] | ||
[[Category: 3',5'-guanosine monophosphate]] | |||
[[Category: 5'-guanosine monophosphate]] | |||
[[Category: gaf domain]] | [[Category: gaf domain]] | ||
[[Category: hydrolase]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:00:53 2008'' | ||
Revision as of 11:00, 26 March 2008
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| , resolution 2.86Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Gene: | PDE2A (Mus musculus) | ||||||
| Activity: | 3',5'-cyclic-GMP phosphodiesterase, with EC number 3.1.4.35 | ||||||
| Domains: | GAF | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains
OverviewOverview
Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of cGMP to the GAF domain causes an activation of the catalytic activity by a mechanism that apparently is shared even in the adenylyl cyclase of Anabaena, an organism separated from mouse by 2 billion years of evolution. The 2.9-A crystal structure of the mouse PDE2A regulatory segment reported in this paper reveals that the GAF A domain functions as a dimerization locus. The GAF B domain shows a deeply buried cGMP displaying a new cGMP-binding motif and is the first atomic structure of a physiological cGMP receptor with bound cGMP. Moreover, this cGMP site is located well away from the region predicted by previous mutagenesis and structural genomic approaches.
About this StructureAbout this Structure
1MC0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding., Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA, Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13260-5. Epub 2002 Sep 23. PMID:12271124
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