Cadherin: Difference between revisions
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{{STRUCTURE_1q1p| PDB=1q1p | SIZE=400| SCENE=Cadherin/Cv/1 |right|CAPTION=Epithelial cadherin complex with Ca+2 ions, [[1q1p]] }} | {{STRUCTURE_1q1p| PDB=1q1p | SIZE=400| SCENE=Cadherin/Cv/1 |right|CAPTION=Epithelial cadherin complex with Ca+2 ions, [[1q1p]] }} | ||
<StructureSection load='3lne' size='450' side='right' scene= caption='Lymnaea acetylcholine-binding protein pentamer complex with acetylcholine (PDB code 3wip)'> | |||
== Function == | |||
[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental). The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.<br /> | [[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental). The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.<br /> | ||
*'''Desmogleins''' (Des-CDH) are CDH found in desmosomes. | *'''Desmogleins''' (Des-CDH) are CDH found in desmosomes. | ||
== Structural highlights == | |||
The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. | |||
== 3D Structures of Cadherin == | == 3D Structures of Cadherin == | ||