Aspartate-semialdehyde dehydrogenase

Function Aspartate-semialdehyde dehydrogenase (ASADH) is an enzyme which is part of the biosynthesis of amino acids in bacteria, plants and fungi. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. Structural highlights ASADH contains 2 domains. The N terminal domain contains the active site and the NADP-binding site. The active site contains a cysteine residue which binds to inhibitors. The C terminal contains the homodimer intersubunit contacts.

spinqualitylabelsall models Aspartate-semialdehyde dehydrogenase complex with NADP and substrate analog (PDB code 1mb4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Aspartate-semialdehyde dehydrogenase3D Structures of Aspartate-semialdehyde dehydrogenase

Updated on 10-November-2015

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• Aspartate-semialdehyde dehydrogenase
  • 2qz9, 1mc4 – VcASADH II – Vibrio cholerae
    
  • 2yv3 – ASADH – Thermus thermiphilus
    
  • 1t4d, 1t4b, 1brm - EcASADH β - Escherichia coli
    
  • 1pu2, 1oza, 1pr3, 1ps8 - HiASADH (mutant) – Haemophilus influenzae
    
  • 1nwc – HiASADH
    
  • 1nwh – HiASADH reaction intermediate
    
  • 2gyy – SpASADH – Streptococcus pneumonia
    
  • 3uw3 - ASADH – Burkholderia thailandensis
• ASADH binary complex
  • 2r00 - VcASADH II + ASA
    
  • 3llg, 3vos – MtASADH + glycerol+ anion – Mycobacterium tuberculosis
    
  • 3hsk – ASADH + NADP – Candida albicans
    
  • 1ys4 - ASADH + NADP – Methanocaldococcus jannaschii
    
  • 1nx6 - HiASADH reaction intermediate +Pi
    
  • 1ta4 - HiASADH + As
    
  • 1tb4 - HiASADH + IO4
    
  • 1q2x - HiASADH (mutant) + ASA
    
  • 2gz1 - SpASADH + NADP
    
  • 2gz2 - SpASADH + ADP
    
  • 3pyl - SpASADH + diaminopropionate
    
  • 3q0e - VcASADH + cysteine sulfoxide
    
  • 3q1l - SpASADH + cysteamine
    
  • 3tz6 - MtASADH + cysteine
• ASADH ternary complex
  • 1pqu - HiASADH (mutant) + NADP + cacodylate + substrate analog
    
  • 1pqp - HiASADH (mutant) + ASA + Pi
    
  • 1gl3 - EcASADH β + NADP + substrate analog
    
  • 1mb4 - VcASADH + NADP + substrate analog
    
  • 3pzr - VcASADH + NADP + carbamoyl-cysteine
    
  • 2gz3 - SpASADH + NADP + ASA
    
  • 3pwk, 3pws - SpASADH + NADP + aminoadipate
    
  • 3pyx - SpASADH + NADP + aminoterephthalate
    
  • 3pzb - SpASADH + NADP + diaminopropionate
    
  • 3q11, 4r3n, 4r3w, 4r41, 4r4j, 4r51, 4r54, 4r5h - SpASADH + NADP + inhibitor
    
  • 4r5m - VcASADH I + NADP + inhibitor