Argonaute: Difference between revisions

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João Rodrigues, Michal Harel, Joel L. Sussman, Alexander Berchansky

Revision as of 13:26, 2 February 2015 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 13:51, 4 November 2015 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	<Structure load='4EI1' size='350' frame='true' align='right' caption='X-ray structure of the entire human Argonaute2 protein complex with RNA (PDB [[4ei1]]) at 2.3Å resolution ' scene='Argonaute/Initial/1'/>		<Structure load='4EI1' size='350' frame='true' align='right' caption='X-ray structure of the entire human Argonaute2 protein complex with RNA (red) (PDB [[4ei1]]) at 2.3Å resolution ' scene='Argonaute/Initial/1'/>
	The '''Argonaute''' protein is a component of the RISC complex, central to the [[RNA_Interference\|RNA-induced silencing]] in eukaryotic organisms <ref name='ref1'>pmid 22539551</ref>. It is found in all higher eukaryotes and it plays an important role in a variety of processes as diverse as embryonic development, cell diferentiation and transposon silencing. These proteins are evolutionarily conserved and can be divided in three subfamilies: Ago, Piwi and Wago. The first are ubiquitously expressed and interact with siRNAs or miRNAs to participate in post-transcriptional gene silencing, both by destabilizing mRNA or by repressing the translation event. Piwi proteins are generally restricted to the germ line and associate piRNAs to mediate silencing of mobile genetic elements <ref name='ref2'>pmid 18304383</ref>. The third and final subclass, Wago, are worm specific. For more details see [[RNA Interference]].		The '''Argonaute''' protein is a component of the RISC complex, central to the [[RNA_Interference\|RNA-induced silencing]] in eukaryotic organisms <ref name='ref1'>pmid 22539551</ref>. It is found in all higher eukaryotes and it plays an important role in a variety of processes as diverse as embryonic development, cell diferentiation and transposon silencing. These proteins are evolutionarily conserved and can be divided in three subfamilies: Ago, Piwi and Wago. The first are ubiquitously expressed and interact with siRNAs or miRNAs to participate in post-transcriptional gene silencing, both by destabilizing mRNA or by repressing the translation event. Piwi proteins are generally restricted to the germ line and associate piRNAs to mediate silencing of mobile genetic elements <ref name='ref2'>pmid 18304383</ref>. The third and final subclass, Wago, are worm specific. For more details see [[RNA Interference]].