Antithrombin: Difference between revisions
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<StructureSection load='3evj' size='340' side='right' caption=' | <StructureSection load='3evj' size='340' side='right' caption='Glycosylated human antithrombin III complex with heparin (PDB code [[2ohy]])' scene=''> | ||
== Function == | == Function == | ||
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br /> | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br /> | ||
▪ α-AT contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ▪ '''α-AT''' contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ||
▪ β-AT contains only 3 occupied glycosylation sites.<br /> | ▪ '''β-AT''' contains only 3 occupied glycosylation sites.<br /> | ||
▪ AT-I refers to the absorption of thrombin to fibrin.<br /> | ▪ '''AT-I''' refers to the absorption of thrombin to fibrin.<br /> | ||
▪ AT-II and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ▪ '''AT-II''' and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ||
▪ AT-III inactivates thrombin in plasma.<br /> | ▪ '''AT-III''' inactivates thrombin in plasma.<br /> | ||
▪ AT-IV becomes activated during blood coagulation.<br /> | ▪ '''AT-IV''' becomes activated during blood coagulation.<br /> | ||
See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | ||