Antithrombin: Difference between revisions

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Michal Harel, Alexander Berchansky

Revision as of 12:24, 3 November 2015 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 12:25, 3 November 2015 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	{{~~STRUCTURE_13evj~~\| PDB=3evj \| SIZE=400\| SCENE= \|right\|CAPTION=Antithrombin (beige) complex with thrombin heavy chain (pink), light chain (green) and heparin polysaccharide, [[1tb6]] }}		{{STRUCTURE_3evj\| PDB=3evj \| SIZE=400\| SCENE= \|right\|CAPTION=Antithrombin (beige) complex with thrombin heavy chain (pink), light chain (green) and heparin polysaccharide, [[1tb6]] }}

	'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].		'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]].