14-3-3 protein: Difference between revisions
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== Disease == | == Disease == | ||
Elevated levels of PRS are found in patients with Creutzfeld-Jakob disease. | Elevated levels of PRS are found in patients with Creutzfeld-Jakob disease (CJD). PRS are associated with Parkinson Disease (PD) and with Alzheimer Disease (AD) based on their localization and their binding withPD and AD-associated proteins. | ||
== Relevance == | == Relevance == | ||
PRS are tested as biomarkers for CJD, PD and AD. | |||
== Structural highlights == | == Structural highlights == | ||
PRS are homo- and heterodimers containing 9 antiparallel α-helices. Three of the helices form the dimerization interaction and four others are involved in ligand binding. | |||
</StructureSection> | </StructureSection> | ||