2qac: Difference between revisions
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|PDB= 2qac |SIZE=350|CAPTION= <scene name='initialview01'>2qac</scene>, resolution 1.70Å | |PDB= 2qac |SIZE=350|CAPTION= <scene name='initialview01'>2qac</scene>, resolution 1.70Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= PFL2225w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7]) | |GENE= PFL2225w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7]) | ||
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5126 FRQ1]</span> | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qac OCA], [http://www.ebi.ac.uk/pdbsum/2qac PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2qac RCSB]</span> | |||
}} | }} | ||
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[[Category: structural genomics of pathogenic protozoa consortium]] | [[Category: structural genomics of pathogenic protozoa consortium]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:42:29 2008'' | ||
Revision as of 07:42, 26 March 2008
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| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | PFL2225w (Plasmodium falciparum 3D7) | ||||||
| Domains: | FRQ1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The closed MTIP-MyosinA-tail complex from the malaria parasite invasion machinery
OverviewOverview
The Myosin A-tail interacting protein (MTIP) of the malaria parasite links the actomyosin motor of the host cell invasion machinery to its inner membrane complex. We report here that at neutral pH Plasmodium falciparum MTIP in complex with Myosin A adopts a compact conformation, with its two domains completely surrounding the Myosin A-tail helix, dramatically different from previously observed extended MTIP structures. Crystallographic and mutagenesis studies show that H810 and K813 of Myosin A are key players in the formation of the compact MTIP:Myosin A complex. Only the unprotonated state of Myosin A-H810 is compatible with the compact complex. Most surprisingly, every side-chain atom of Myosin A-K813 is engaged in contacts with MTIP. While this side-chain was previously considered to prevent a compact conformation of MTIP with Myosin A, it actually appears to be essential for the formation of the compact complex. The hydrophobic pockets and adaptability seen in the available series of MTIP structures bodes well for the discovery of inhibitors of cell invasion by malaria parasites.
About this StructureAbout this Structure
2QAC is a Protein complex structure of sequences from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
ReferenceReference
The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery., Bosch J, Turley S, Roach CM, Daly TM, Bergman LW, Hol WG, J Mol Biol. 2007 Sep 7;372(1):77-88. Epub 2007 Jun 9. PMID:17628590
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Plasmodium falciparum 3d7
- Protein complex
- Bergman, L W.
- Bosch, J.
- Daly, T M.
- Hol, W G.J.
- Roach, C M.
- SGPP, Structural Genomics of Pathogenic Protozoa Consortium.
- Turley, S.
- Malaria invasion
- Protein structure initiative
- Psi
- Sgpp
- Structural genomic
- Structural genomics of pathogenic protozoa consortium