Cyclin-dependent kinase regulatory subunit

spinqualitylabelsall models PDB ID 1x9d Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Human CKS 1 complex with CDK1 (PDB code 1x9d) Ligands: , , , Gene: MAN1B1 (Homo sapiens) Activity: Mannosyl-oligosaccharide 1,2-alpha-mannosidase, with EC number 3.2.1.113 Related: 1fmi Structural annotation: Resources: CATH : 1X9Da00 InterPro : Ipr001382 Pfam : PF01532 UniProt : Q9UKM7 Functional annotation: Cellular component: membrane endoplasmic reticulum integral to membrane membrane fraction Biological process: oligosaccharide metabolic process protein amino acid N-linked glycosylation metabolic process Molecular function: hydrolase activity hydrolase activity, acting on glycosyl bonds calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB Resources: FirstGlance, OCA, RCSB, PDBsum Coordinates: save as pdb, mmCIF, xml Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in the figure at top left. CKS1 is essential for CDK5 functioning in neuronal diferentiation. CKS exists as hexamer of homodimers and can bind six kinase molecules.

spinqualitylabelsall models Human CKS 1 complex with phosphate (PDB code 1dks) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of cyclin-dependent kinase regulatory subunit3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 12-October-2015

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• CKS
  • 4lpa, 1qb3 – yCKS 1 - yeast
    
  • 3qy2 – yCKS 1 (mutant)
    
  • 1puc, 1sce – fyCKS 1 – fission yeast
    
  • 1dks, 1dkt – hCKS 1 - human
    
  • 1cks – hCKS 2
    
• CKS complexes
  • 4yc6 – hCKS 1 + CDK1
    
  • 1buh – hCKS 1 + CDK2
    
  • 1h4l, 1ung – hCKS 1 + CDK5
    
  • 1unh, 1unl – hCKS 1 + CDK5 + inhibitor
    
  • 3o0g – hCKS 1 + CDK5 + ATP analog
    
  • 2ass – hCKS 1 + Skp1 + Skp2
    
  • 2ast – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide
    
  • 4y72 – hCKS 2 + cyclin B1 + CDK1