4q1r: Difference between revisions

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'''Unreleased structure'''
==Galectin-1 in Complex with Ligand AN027==
 
<StructureSection load='4q1r' size='340' side='right' caption='[[4q1r]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
The entry 4q1r is ON HOLD  until Oct 07 2016
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4q1r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1R FirstGlance]. <br>
Authors: Grimm, C., Bertleff-Zieschang, N.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XU:PROPYL+2-(ACETYLAMINO)-2-DEOXY-4-O-[3-O-({1-[2-(3-HYDROXYPHENYL)-2-OXOETHYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-BETA-D-GALACTOPYRANOSYL]-BETA-D-GLUCOPYRANOSIDE'>2XU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
Description: Galectin-1 in Complex with Ligand AN027
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q1p|4q1p]], [[4q26|4q26]], [[4q27|4q27]], [[4q2f|4q2f]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1r OCA], [http://pdbe.org/4q1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1r RCSB], [http://www.ebi.ac.uk/pdbsum/4q1r PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bertleff-Zieschang, N]]
[[Category: Bertleff-Zieschang, N]]
[[Category: Grimm, C]]
[[Category: Grimm, C]]
[[Category: Rational drug design]]
[[Category: Sugar binding protein]]

Revision as of 16:48, 7 October 2015

Galectin-1 in Complex with Ligand AN027Galectin-1 in Complex with Ligand AN027

Structural highlights

4q1r is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.[1] [2]

References

  1. ↑ He J, Baum LG. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004 Feb 6;279(6):4705-12. Epub 2003 Nov 14. PMID:14617626 doi:10.1074/jbc.M311183200
  2. ↑ Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, Kamitori S, Hirabayashi J, Nakamura T. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology. 2008 Dec;18(12):1065-73. Epub 2008 Sep 16. PMID:18796645 doi:10.1093/glycob/cwn089

4q1r, resolution 1.47Å

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