Beta-secretase 1: Difference between revisions
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<StructureSection load='4ivt' size='340' side='right' caption='The best structure for Beta-secretase 1 shown: [[4ivt]]' scene=''> | <StructureSection load='4ivt' size='340' side='right' caption='The best structure for Beta-secretase 1 shown: [[4ivt]]' scene=''> | ||
Best example is PDB entry [[4ivt]] and is shown in the viewer.<br> | Best example is PDB entry [[4ivt]] and is shown in the viewer.<br> | ||
== Function == | == Function == | ||
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot [http://www.uniprot.org/uniprot/P56817 P56817]<br> | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot [http://www.uniprot.org/uniprot/P56817 P56817]<br> | ||