2a11: Difference between revisions

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Revision as of 07:19, 26 March 2008

File:2a11.gif

, resolution 2.100Å

Ligands:

Gene:

rnc (Mycobacterium tuberculosis)

Activity:

Ribonuclease III, with EC number 3.1.26.3

Domains:

DSRM, RIBOc, rnc

Resources:

FirstGlance, OCA, PDBsum, JenaLib, RCSB

Coordinates:

save as pdb, mmCIF, xml

Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis

OverviewOverview

RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.

About this StructureAbout this Structure

2A11 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207

Page seeded by OCA on Wed Mar 26 06:19:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 4: / Line 4: @@
 |PDB= 2a11 |SIZE=350|CAPTION= <scene name='initialview01'>2a11</scene>, resolution 2.100&Aring;
 |SITE=
-|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
+|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3]
+|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span>
 |GENE= rnc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
+|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00048 DSRM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00593 RIBOc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00102 rnc]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a11 OCA], [http://www.ebi.ac.uk/pdbsum/2a11 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2a11 RCSB]</span>
 }}
@@ Line 26: / Line 28: @@
 [[Category: Berger, J M.]]
 [[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
-[[Category: CA]]
+[[Category: mycobacterium tuberculosis structural proteomics project (xmtb)]]
-[[Category: protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)]]
+[[Category: nuclease domain]]
+[[Category: protein structure initiative]]
 [[Category: psi]]
-[[Category: ribonuclease; rnase iii; nuclease domain; structural genomic]]
+[[Category: ribonuclease]]
+[[Category: rnase iii]]
+[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:44:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:19:20 2008''