2ogf: Difference between revisions

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<StructureSection load='2ogf' size='340' side='right' caption='[[2ogf]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='2ogf' size='340' side='right' caption='[[2ogf]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ogf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OGF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ogf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OGF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OXG:8-OXOGUANINE'>OXG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OXG:8-OXOGUANINE'>OXG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ0408 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ0408 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ogf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ogf RCSB], [http://www.ebi.ac.uk/pdbsum/2ogf PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2ogf TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ogf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogf OCA], [http://pdbe.org/2ogf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ogf RCSB], [http://www.ebi.ac.uk/pdbsum/2ogf PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2ogf TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Y408_METJA Y408_METJA]] Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).<ref>PMID:22931285</ref>   
[[http://www.uniprot.org/uniprot/MPTD_METJA MPTD_METJA]] Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).[HAMAP-Rule:MF_02130]<ref>PMID:22931285</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Methanocaldococcus jannaschii]]
[[Category: Atcc 43067]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]
[[Category: Burley, S K]]
[[Category: Burley, S K]]

Revision as of 01:35, 12 September 2015

Crystal structure of protein MJ0408 from Methanococcus jannaschii, Pfam DUF372Crystal structure of protein MJ0408 from Methanococcus jannaschii, Pfam DUF372

Structural highlights

2ogf is a 4 chain structure with sequence from Atcc 43067. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:
Gene:MJ0408 (ATCC 43067)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, TOPSAN

Function

[MPTD_METJA] Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).[HAMAP-Rule:MF_02130][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ de Crecy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MW, Murzin AG, White RH. Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate. ACS Chem Biol. 2012 Nov 16;7(11):1807-16. doi: 10.1021/cb300342u. Epub 2012 Sep, 7. PMID:22931285 doi:http://dx.doi.org/10.1021/cb300342u

2ogf, resolution 1.89Å

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