2gow: Difference between revisions
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<StructureSection load='2gow' size='340' side='right' caption='[[2gow]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2gow' size='340' side='right' caption='[[2gow]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2gow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOW FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gow RCSB], [http://www.ebi.ac.uk/pdbsum/2gow PDBsum], [http://www.topsan.org/Proteins/CESG/2gow TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gow OCA], [http://pdbe.org/2gow PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gow RCSB], [http://www.ebi.ac.uk/pdbsum/2gow PDBsum], [http://www.topsan.org/Proteins/CESG/2gow TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2gow" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Cruz, N B.de la]] | [[Category: Cruz, N B.de la]] | ||
Revision as of 19:08, 11 September 2015
Solution structure of BC059385 from Homo sapiensSolution structure of BC059385 from Homo sapiens
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe protein Bc059385, whose solution structure is reported here, is the human representative of a recently identified family of membrane-anchored ubiquitin-fold (MUB) proteins. Analysis of their similarity to ubiquitin indicates that homologous amino acid residues in MUBs form a hydrophobic surface very similar to the recognition patch surrounding Ile-44 in ubiquitin. This suggests that MUBs may interact with proteins containing an alpha-helical motif similar to those of some ubiquitin binding domains. A disordered loop common to MUBs may also provide a second protein interaction site. From the available data, it is probable that this protein is prenylated and associated with the membrane. With <20% identity to ubiquitin, the MUB family further expands the sequence space that maps to the beta-grasp fold, and adds membrane localization to its list of functional roles. Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens.,de la Cruz NB, Peterson FC, Lytle BL, Volkman BF Protein Sci. 2007 Jul;16(7):1479-84. Epub 2007 Jun 13. PMID:17567738[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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