1g62: Difference between revisions

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Revision as of 06:52, 26 March 2008

File:1g62.gif

, resolution 2.5Å

Gene:

TIF6 (Saccharomyces cerevisiae)

Domains:

IF6

Resources:

FirstGlance, OCA, PDBsum, JenaLib, RCSB

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6

OverviewOverview

Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.

About this StructureAbout this Structure

1G62 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899

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OCA

@@ Line 7: / Line 7: @@
 |ACTIVITY=
 |GENE= TIF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00527 IF6]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g62 OCA], [http://www.ebi.ac.uk/pdbsum/1g62 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1g62 RCSB]</span>
 }}
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