1zfu: Difference between revisions
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<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://pdbe.org/1zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1zfu" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Ebony cup]] | ||
[[Category: Buskov, S]] | [[Category: Buskov, S]] | ||
[[Category: Christensen, B]] | [[Category: Christensen, B]] | ||
Revision as of 11:00, 11 September 2015
Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungusPlectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus
Structural highlights
Publication Abstract from PubMedAnimals and higher plants express endogenous peptide antibiotics called defensins. These small cysteine-rich peptides are active against bacteria, fungi and viruses. Here we describe plectasin-the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high, and commercially viable, yield and purity. In vitro, the recombinant peptide was especially active against Streptococcus pneumoniae, including strains resistant to conventional antibiotics. Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin. These findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene. Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.,Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sonksen CP, Ludvigsen S, Raventos D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jorgensen SG, Sorensen MV, Christensen BE, Kjaerulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH Nature. 2005 Oct 13;437(7061):975-80. PMID:16222292[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Ebony cup
- Buskov, S
- Christensen, B
- Christensen, B E
- Elvig-Jorgensen, S G
- Fischer, R L
- Frimodt-Moller, N
- Hansen, M T
- Kjaerulf, S
- Kristensen, H H
- Lehrer, R I
- Ludvigsen, S
- Maria, L De
- Mygind, P H
- Raventos, D
- Schnorr, K
- Sonksen, C P
- Sorensen, M V
- Taboureau, O
- Yaver, D
- Zasloff, M
- Antimicrobial peptide
- Antimicrobial protein
- Cysteine stabilized alpha-beta motif
- Defensin