1urw

File:1urw.gif

spinqualitylabelsall models 1urw, resolution 1.6Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-B]PYRIDAZINE

OverviewOverview

Modification of imidazo[1,2-a]pyridine CDK inhibitors lead to, identification of less lipophilic imidazo[1,2-b]pyridazine series of CDK, inhibitors. Although several equivalent compounds from these two series, have similar structure and show similar CDK activity, the SAR of the two, series differs significantly. Protein inhibitor structure determination, has confirmed differences in binding mode and given some understanding of, these differences in SAR. Potent and selective imidazo[1,2-b]pyridazine, inhibitors of CDK2 have been identified, which show >1 microM plasma, levels following a 2mg/kg oral dose to mice.

About this StructureAbout this Structure

1URW is a Single protein structure of sequence from Homo sapiens with ACE and I1P as ligands. Active as Transferred entry: 2.7.11.1, with EC number 2.7.1.37 Structure known Active Site: AC2. Full crystallographic information is available from OCA.

ReferenceReference

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors., Byth KF, Cooper N, Culshaw JD, Heaton DW, Oakes SE, Minshull CA, Norman RA, Pauptit RA, Tucker JA, Breed J, Pannifer A, Rowsell S, Stanway JJ, Valentine AL, Thomas AP, Bioorg Med Chem Lett. 2004 May 3;14(9):2249-52. PMID:15081018

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