2ab9: Difference between revisions
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<StructureSection load='2ab9' size='340' side='right' caption='[[2ab9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2ab9' size='340' side='right' caption='[[2ab9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_sunflower Common sunflower]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AB9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ab9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/2ab9 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ab9 OCA], [http://pdbe.org/2ab9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/2ab9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2ab9" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Common sunflower]] | ||
[[Category: Craik, D J]] | [[Category: Craik, D J]] | ||
[[Category: Foley, F M]] | [[Category: Foley, F M]] | ||
Revision as of 17:41, 10 September 2015
Discovery, structural determination and processing of the precursor protein that produces the cyclic trypsin inhibitor SFTI-1Discovery, structural determination and processing of the precursor protein that produces the cyclic trypsin inhibitor SFTI-1
Structural highlights
Function[SFTI1_HELAN] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.[1] Publication Abstract from PubMedBackbone-cyclized proteins are becoming increasingly well known, although the mechanism by which they are processed from linear precursors is poorly understood. In this report the sequence and structure of the linear precursor of a cyclic trypsin inhibitor, sunflower trypsin inhibitor 1 (SFTI-1) from sunflower seeds, is described. The structure indicates that the major elements of the reactive site loop of SFTI-1 are present before processing. This may have importance for a protease-mediated cyclizing reaction as the rigidity of SFTI-1 may drive the equilibrium of the reaction catalyzed by proteolytic enzymes toward the formation of a peptide bond rather than the normal cleavage reaction. The occurrence of residues in the SFTI-1 precursor susceptible to cleavage by asparaginyl proteases strengthens theories that involve this enzyme in the processing of SFTI-1 and further implicates it in the processing of another family of plant cyclic proteins, the cyclotides. The precursor reported here also indicates that despite strong active site sequence homology, SFTI-1 has no other similarities with the Bowman-Birk trypsin inhibitors, presenting interesting evolutionary questions. Discovery, structural determination, and putative processing of the precursor protein that produces the cyclic trypsin inhibitor sunflower trypsin inhibitor 1.,Mulvenna JP, Foley FM, Craik DJ J Biol Chem. 2005 Sep 16;280(37):32245-53. Epub 2005 Jul 21. PMID:16036912[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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