1c3t: Difference between revisions
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<StructureSection load='1c3t' size='340' side='right' caption='[[1c3t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1c3t' size='340' side='right' caption='[[1c3t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1c3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1c3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C3T FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c3t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c3t RCSB], [http://www.ebi.ac.uk/pdbsum/1c3t PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c3t OCA], [http://pdbe.org/1c3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c3t RCSB], [http://www.ebi.ac.uk/pdbsum/1c3t PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1c3t" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Desjarlais, J R]] | [[Category: Desjarlais, J R]] | ||
[[Category: Handel, T M]] | [[Category: Handel, T M]] | ||
Revision as of 13:30, 10 September 2015
ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITYROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedWe present direct evidence for a change in protein structural specificity due to hydrophobic core packing. High resolution structural analysis of a designed core variant of ubiquitin reveals that the protein is in slow exchange between two conformations. Examination of side-chain rotamers indicates that this dynamic response and the lower stability of the protein are coupled to greater strain and mobility in the core. The results suggest that manipulating the level of side-chain strain may be one way of fine tuning the stability and specificity of proteins. Rotamer strain as a determinant of protein structural specificity.,Lazar GA, Johnson EC, Desjarlais JR, Handel TM Protein Sci. 1999 Dec;8(12):2598-610. PMID:10631975[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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