1y8e: Difference between revisions
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|PDB= 1y8e |SIZE=350|CAPTION= <scene name='initialview01'>1y8e</scene>, resolution 2.2Å | |PDB= 1y8e |SIZE=350|CAPTION= <scene name='initialview01'>1y8e</scene>, resolution 2.2Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=SVR:8,8 | |LIGAND= <scene name='pdbligand=SVR:8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID'>SVR</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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[[Category: beta barrel]] | [[Category: beta barrel]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:19:17 2008'' | ||
Revision as of 15:19, 23 March 2008
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VCP:Suramin Complex
OverviewOverview
Suramin is a competitive inhibitor of heparin binding to many proteins, including viral envelope proteins, protein tyrosine phosphatases, and fibroblast growth factors (FGFs). It has been clinically evaluated as a potential therapeutic in treatment of cancers caused by unregulated angiogenesis, triggered by FGFs. Although it has shown clinical promise in treatment of several cancers, suramin has many undesirable side effects. There is currently no experimental structure that reveals the molecular interactions responsible for suramin inhibition of heparin binding, which could be of potential use in structure-assisted design of improved analogues of suramin. We report the structure of suramin, in complex with the heparin-binding site of vaccinia virus complement control protein (VCP), which interacts with heparin in a geometrically similar manner to many FGFs. The larger than anticipated flexibility of suramin manifested in this structure, and other details of VCP-suramin interactions, might provide useful structural information for interpreting interactions of suramin with many proteins.
About this StructureAbout this Structure
1Y8E is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for antagonism by suramin of heparin binding to vaccinia complement protein., Ganesh VK, Muthuvel SK, Smith SA, Kotwal GJ, Murthy KH, Biochemistry. 2005 Aug 16;44(32):10757-65. PMID:16086578
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