1xud: Difference between revisions
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|PDB= 1xud |SIZE=350|CAPTION= <scene name='initialview01'>1xud</scene>, resolution 1.800Å | |PDB= 1xud |SIZE=350|CAPTION= <scene name='initialview01'>1xud</scene>, resolution 1.800Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PB4:N,N | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PB4:N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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[[Category: non-zinc binding inhibitor]] | [[Category: non-zinc binding inhibitor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:16:15 2008'' | ||
Revision as of 15:16, 23 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor
OverviewOverview
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.
About this StructureAbout this Structure
1XUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640
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