1pm1: Difference between revisions
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<StructureSection load='1pm1' size='340' side='right' caption='[[1pm1]], [[Resolution|resolution]] 1.10Å' scene=''> | <StructureSection load='1pm1' size='340' side='right' caption='[[1pm1]], [[Resolution|resolution]] 1.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1pm1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1pm1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PM1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pee|1pee]], [[1euo|1euo]], [[1ikj|1ikj]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pee|1pee]], [[1euo|1euo]], [[1ikj|1ikj]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pm1 RCSB], [http://www.ebi.ac.uk/pdbsum/1pm1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm1 OCA], [http://pdbe.org/1pm1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pm1 RCSB], [http://www.ebi.ac.uk/pdbsum/1pm1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Rhopr]] | ||
[[Category: Montfort, W R]] | [[Category: Montfort, W R]] | ||
[[Category: Weichsel, A]] | [[Category: Weichsel, A]] | ||
Revision as of 11:09, 10 September 2015
Crystal structure of nitrophorin 2 L122V/L132V mutant complex with imidazoleCrystal structure of nitrophorin 2 L122V/L132V mutant complex with imidazole
Structural highlights
Function[NP2_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity). Specifically inhibits factor IXa-catalyzed activation of factor X in the presence of calcium and phospholipids irrespective of the presence or absence of factor VIIIa. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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