4x1g: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of the hPXR-LBD in complex with the synthetic estrogen 17alpha-ethinylestradiol and the pesticide trans-nonachlor==
+<StructureSection load='4x1g' size='340' side='right' caption='[[4x1g]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-The entry 4x1g is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x1g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1G FirstGlance]. <br>
-Authors: DELFOSSE, V., HUET, T., BOURGUET, W.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3WF:ETHINYL+ESTRADIOL'>3WF</scene>, <scene name='pdbligand=3WG:TRANS-NONACHLOR'>3WG</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x1f|4x1f]]</td></tr>
-Description: Crystal structure of the hPXR-LBD in complex with the synthetic estrogen 17alpha-ethinylestradiol and the pesticide trans-nonachlor
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x1g RCSB], [http://www.ebi.ac.uk/pdbsum/4x1g PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Delfosse, V]]
+== Function ==
-[[Category: Bourguet, W]]
+[[http://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN]] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
-[[Category: Huet, T]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: BOURGUET, W]]
+[[Category: DELFOSSE, V]]
+[[Category: HUET, T]]
+[[Category: Estrogen]]
+[[Category: Gene regulation]]
+[[Category: Hormone receptor]]
+[[Category: Pesticide]]