4y1t: Difference between revisions

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'''Unreleased structure'''
==Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes==
 
<StructureSection load='4y1t' size='340' side='right' caption='[[4y1t]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
The entry 4y1t is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4y1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y1T FirstGlance]. <br>
Authors: Conroy, P.J., Yagi, H., Whisstock, J.C., Norton, R.S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y1s|4y1s]]</td></tr>
Description: Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y1t RCSB], [http://www.ebi.ac.uk/pdbsum/4y1t PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Conroy, P.J]]
== Function ==
[[Category: Norton, R.S]]
[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conroy, P J]]
[[Category: Norton, R S]]
[[Category: Whisstock, J C]]
[[Category: Yagi, H]]
[[Category: Yagi, H]]
[[Category: Whisstock, J.C]]
[[Category: C2 domain]]
[[Category: Calcium binding]]
[[Category: Immune system]]
[[Category: Perforin]]

Revision as of 15:30, 2 September 2015

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranesStructural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Structural highlights

4y1t is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[PERF_MOUSE] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.[1] [2] [3] [4] [5]

References

  1. ↑ Shinkai Y, Takio K, Okumura K. Homology of perforin to the ninth component of complement (C9). Nature. 1988 Aug 11;334(6182):525-7. PMID:3261391 doi:http://dx.doi.org/10.1038/334525a0
  2. ↑ Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 1994 May 5;369(6475):31-7. PMID:8164737 doi:http://dx.doi.org/10.1038/369031a0
  3. ↑ Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR. Immune function in mice lacking the perforin gene. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10854-8. PMID:7526382
  4. ↑ Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H, Whisstock JC, Voskoboinik I, Trapani JA. The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity. 2009 May;30(5):684-95. doi: 10.1016/j.immuni.2009.03.016. Epub 2009 May, 14. PMID:19446473 doi:10.1016/j.immuni.2009.03.016
  5. ↑ Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC. The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature. 2010 Nov 18;468(7322):447-51. Epub 2010 Oct 31. PMID:21037563 doi:10.1038/nature09518

4y1t, resolution 2.67Å

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