4r6a: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human TLR8 in complex with Hybrid-2==
 
<StructureSection load='4r6a' size='340' side='right' caption='[[4r6a]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
The entry 4r6a is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4r6a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6A FirstGlance]. <br>
Authors: Tanji, H., Ohto, U., Shimizu, T.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=HB2:1-(4-AMINO-2-BUTYL-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL)-2-METHYLPROPAN-2-OL'>HB2</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r6a RCSB], [http://www.ebi.ac.uk/pdbsum/4r6a PDBsum]</span></td></tr>
Description: Crystal structure of human TLR8 in complex with Hybrid-2
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Tanji, H]]
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ohto, U]]
[[Category: Ohto, U]]
[[Category: Shimizu, T]]
[[Category: Shimizu, T]]
[[Category: Tanji, H]]
[[Category: Antiviral and antitumor drug binding]]
[[Category: Glycosylation]]
[[Category: Innate immunity]]
[[Category: Leucine rich repeat]]
[[Category: Rna binding protein]]
[[Category: Rna receptor]]
[[Category: Rna recognition]]
[[Category: Secreted]]
[[Category: Ssrna]]
[[Category: Structure-based ligand design]]
[[Category: Vaccine adjuvant]]

Revision as of 16:32, 26 August 2015

Crystal structure of human TLR8 in complex with Hybrid-2Crystal structure of human TLR8 in complex with Hybrid-2

Structural highlights

4r6a is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]

References

  1. ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200

4r6a, resolution 2.10Å

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