2bj6: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
2BJ6 is a | 2BJ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: rna]] | [[Category: rna]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:32:02 2007'' | ||
Revision as of 15:26, 5 November 2007
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CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID
OverviewOverview
The crystal structure of a decameric HNA/RNA (HNA =, 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the, RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid, duplex between a naturally occurring nucleic acid and a strand, which is, fully modified to contain a six-membered ring instead of ribose. The, presence of four duplex helices in the asymmetric unit allows for a, detailed discussion of hydration, which revealed a tighter spinelike, backbone hydration for the HNA- than for the RNA-strands. The reinforced, backbone hydration is suggested to contribute significantly to the, exceptional stability of HNA-containing duplexes and might be one of the, causes for the evolutionary preference for ribose-derived nucleic acids.
About this StructureAbout this Structure
2BJ6 is a Single protein structure of sequence from [1] with SO4 as ligand. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
ReferenceReference
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130
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