5a0c: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor==
+<StructureSection load='5a0c' size='340' side='right' caption='[[5a0c]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-The entry 5a0c is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5a0c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0C FirstGlance]. <br>
-Authors: vonNussbaum, F., Li, V.M.-J., Allerheiligen, S., Anlauf, S., Baerfacker, L., Bechem, M., Delbeck, M., Fitzgerald, M.F., Gerisch, M., Gielen-Haertwig, H., Haning, H., Karthaus, D., Lang, D., Lustig, K., Meibom, D., Mittendorf, J., Rosentreter, U., Schaefer, M., Schaefer, S., Schamberger, J., Telan, L.A., Tersteegen, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JJV:(6S)-6-(4-CYANO-2-METHYLSULFONYL-PHENYL)-4-METHYL-2-OXIDANYLIDENE-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE'>JJV</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a09|5a09]], [[5a0a|5a0a]], [[5a0b|5a0b]]</td></tr>
-Description: Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0c RCSB], [http://www.ebi.ac.uk/pdbsum/5a0c PDBsum]</span></td></tr>
-[[Category: Schamberger, J]]
+</table>
-[[Category: Mittendorf, J]]
+== Disease ==
-[[Category: Karthaus, D]]
+[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[http://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref>   Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[http://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>
-[[Category: Li, V.M.-J]]
+== Function ==
-[[Category: Tersteegen, A]]
+[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>
-[[Category: Lustig, K]]
+== References ==
-[[Category: Haning, H]]
+<references/>
-[[Category: Baerfacker, L]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Leukocyte elastase]]
 [[Category: Allerheiligen, S]]
-[[Category: Fitzgerald, M.F]]
 [[Category: Anlauf, S]]
-[[Category: Telan, L.A]]
+[[Category: Baerfacker, L]]
-[[Category: Schaefer, M]]
 [[Category: Bechem, M]]
 [[Category: Delbeck, M]]
+[[Category: Fitzgerald, M F]]
+[[Category: Gerisch, M]]
+[[Category: Gielen-Haertwig, H]]
+[[Category: Haning, H]]
+[[Category: Karthaus, D]]
 [[Category: Lang, D]]
-[[Category: Gielen-Haertwig, H]]
+[[Category: Li, V M.J]]
-[[Category: Gerisch, M]]
+[[Category: Lustig, K]]
-[[Category: Vonnussbaum, F]]
-[[Category: Schaefer, S]]
 [[Category: Meibom, D]]
+[[Category: Mittendorf, J]]
 [[Category: Rosentreter, U]]
+[[Category: Schaefer, M]]
+[[Category: Schaefer, S]]
+[[Category: Schamberger, J]]
+[[Category: Telan, L A]]
+[[Category: Tersteegen, A]]
+[[Category: VonNussbaum, F]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase- inhibitor complex]]
+[[Category: Protease]]
+[[Category: Trypsin family fold]]