Porin: Difference between revisions

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[[Porin]] or '''Outer Membrane Proteins''' '''(Omps)''' act as channels which allow passive diffusion of sugars, ions and amino acids.  They are beta barrel proteins which traverse the cell membrane.  In ''E. coli'' they are named according to their genes: C, F, G (OmpC, OmpF, OmpG). Voltage-Dependent Anion Channel (VDAC) are ion channel Omps found in outer mitochondrial membrane.  In Pseudomonas aeruginosa the porin gene products are named OprD, OprE, OprK, OprP.  '''Maltoporin''' (LamB) facilitates the diffusion of maltodextrin across the membrane.  See more details in<br />
[[Porin]] or '''Outer Membrane Proteins''' '''(Omps)''' act as channels which allow passive diffusion of sugars, ions and amino acids.  They are beta barrel proteins which traverse the cell membrane.  In ''E. coli'' they are named according to their genes: C, F, G, etc. (OmpC, OmpF, OmpG). Voltage-Dependent Anion Channel (VDAC) are ion channel Omps found in outer mitochondrial membrane.  In ''Pseudomonas aeruginosa'' the porin gene products are named OprD, OprE, OprK, OprP, etc. and OpdC, OpdH, etc.  '''Maltoporin''' (LamB) facilitates the diffusion of maltodextrin across the membrane.  See more details in<br />
*[[Osmoporin OmpC (E. coli)]]<br />
*[[Osmoporin OmpC (E. coli)]]<br />
*[[OmpF]]<br />  
*[[OmpF]]<br />  
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


*Porin
*OmpA


**[[2xe5]], [[2xe1]], [[2xe2]], [[2xe3]], [[2j1n]], [[2xg6]] – EcOmpC – ''Escherichia coli''<br />
**[[3nb3]] – EcOmpA + EcOmpC – ''Escherichia coli'' – EM<br />
**[[3k19]], [[3k1b]], [[2zfg]], [[1omf]], [[2omf]], [[1opf]], [[3poq]], [[3pou]], [[3pox]], [[4jfb]], [[4lse]], [[4lsf]], [[4lsh]], [[4lsi]] – EcOmpF<br />
**[[1bxw]], [[1qjp]] – EcOmpA transmembrane domain (mutant)<br />
**[[3nb3]] – EcOmpA + EcOmpC - EM<br />
**[[2jmm]] – EcOmpA transmembrane domain - NMR<br />
**[[2zle]] - EcOmpC + protease DO – EM<br />
**[[1g90]], [[2ge4]] – EcOmpA transmembrane domain (mutant) - NMR<br />
**[[4a8d]] - EcOmpC + DEGP – EM<br />
**[[2kgw]] – MtOmpA C terminal – ''Mycobacterium tuberculosis'' – NMR<br />
**[[2kgw]] – MtOmpA C terminal – ''Mycobacterium tuberculosis'' – NMR<br />
**[[2ksm]] – MtOmpA BON domain – NMR<br />
**[[2ksm]] – MtOmpA BON domain – NMR<br />
**[[3upg]], [[3uu2]] – OmpC – ''Salmonella enterica''<br />
**[[2k0l]] – KpOmpA transmembrane domain – ''Klebsiella pneumoniae'' - NMR<br />
**[[1hxt]], [[1hxu]], [[1hxx]], [[1bt9]], [[1gfm]], [[1gfn]], [[1gfo]], [[1gfp]], [[1gfq]], [[1mpf]] – EcOmpF (mutant)<br />
**[[4erh]] – SeOmpA residues 205-349 – ''Salmonella enterica''<br />
**[[2iwv]], [[2iww]], [[2f1c]] - EcOmpG<br />
 
**[[2x9k]] - EcOmpG (mutant)<br />
*OmpB
**[[2wjq]], [[2wjr]] – EcOmp NANC<br />
 
**[[1pho]] - EcOmp<br />
**[[3a2r]] – NmOmpB – ''Neisseria meningitides''<br />
**[[3a2r]] – NmOmpB – ''Neisseria meningitides''<br />
**[[3sy9]] – PaOprC – ''Pseudomonas aeruginosa''<br />
**[[3a2s]], [[3a2t]] – NmOmpB+sugars<br />
**[[3a2u]] - NmOmpB+AMPPNP<br />
**[[4gey]], [[4gf4]] – OmpB – ''Pseudomonas putida''<br />
 
*OmpC
 
**[[2xe5]], [[2xe1]], [[2xe2]], [[2xe3]], [[2j1n]], [[2xg6]] – EcOmpC <br />
**[[2zle]] - EcOmpC + protease DO – EM<br />
**[[4a8d]] - EcOmpC + DEGP – EM<br />
**[[2j4u]] – EcOmpC+lactotransferrin fragment<br />
**[[3upg]], [[3uu2]] – SeOmpC <br />
 
*OmpF
 
**[[3k19]], [[3k1b]], [[2zfg]], [[1omf]], [[2omf]], [[1opf]], [[3poq]], [[3pou]], [[3pox]], [[4jfb]], [[4lse]], [[4lsf]], [[4lsh]], [[4lsi]] – EcOmpF<br />
**[[1hxt]], [[1hxu]], [[1hxx]], [[1bt9]], [[1gfm]], [[1gfn]], [[1gfo]], [[1gfp]], [[1gfq]], [[1mpf]] – EcOmpF (mutant) <br />
**[[2zld]] – EcOmpF+colicin E3<br />
**[[3o0e]] - EcOmpF+colicin peptide<br />
**[[3hw9]], [[3hwb]] – EcOmpF+ions<br />
**[[3fyx]] – EcOmpF+dibenzo-18-crown-6<br />
**[[4gcp]], [[4gcq]], [[4gcs]] – EcOmpF + antibiotic<br />
**[[3nsg]] – StOmpF - ''Salmonella typhimurium''<br />
**[[4kr4]], [[4kr8]], [[4kra]] – StOmpF + antibiotics<br />
 
*OmpG
 
**[[2iwv]], [[2iww]], [[2f1c]], [[4ctd]] – EcOmpG<br />
**[[2x9k]], [[2wvp]] - EcOmpG (mutant) <br />
**[[2jqy]] – EcOmpG - NMR<br />
 
*OmpK
 
**[[1osm]] – KpOmpK36 <br />
 
*OmpR
 
**[[1opc]] - EcOmpR C terminal<br />
 
*Omp32
 
**[[2fgr]] - DaOmp32 – ''Delftia acidovorans''<br />
**[[1e54]] – Omp32+sulfate – ''Comamonas acidovorans''<br />
**[[2fgq]] – DaOmp32+malate<br />
 
*OprB
 
**[[4gf4]], [[4gey]] – PaOprB – ''Pseudomonas aeruginosa''<br />
 
*OprD
 
**[[2odj]], [[3sy7]], [[4foz]] – PaOprD<br />
**[[2odj]], [[3sy7]], [[4foz]] – PaOprD<br />
*OprE
**[[4frx]] – PaOprE<br />
**[[4frx]] – PaOprE<br />
**[[3szd]] - PaOpdF<br />
 
*OprF
 
**[[3szd]] – PaOprF<br />
**[[4rlc]] – PaOprF N terminal<br />
**[[4rlc]] – PaOprF N terminal<br />
**[[3t20]] – PaOprH<br />
 
*OprG
 
**[[2x27]] - PaOprG<br />
 
*OprH
 
**[[2lhf]] – PaOprH - NMR<br />
 
*OprK
 
**[[2qtk]], [[2y2x]], [[3sys]] – PaOprK<br />
**[[2qtk]], [[2y2x]], [[3sys]] – PaOprK<br />
*OprL
**[[3t0s]] - PaOprL<br />
**[[3t0s]] - PaOprL<br />
**[[2y0k]], [[2y0l]], [[3szv]] – PaOprO<br />
 
**[[3syb]] – PaOprP<br />
*OprM
**[[3t24]] - PaOprQ<br />
 
**[[3d5k]], [[1wp1]], [[4y1k]] - PaOprM<br />
 
*OprP
 
**[[2o4v]] – PaOprP+phosphate<br />
 
*OprQ
 
**[[3t24]] – PaOprQ<br />
 
*OpdC (histidine porin)
 
**[[3sy9]] – PaOprC <br />
 
*OpdH (cis-aconitate porin)
 
**[[3t20]] – PaOprH<br />
 
*OpdO (pyroglutatmate porin)
 
**[[2y0k]], [[2y0l]], [[3szv]] – PaOpdO<br />
 
*OpdP (glycine-glutamate dipeptide porin)
 
**[[3syb]] – PaOpdP<br />
 
*Omp
 
**[[1pho]] - EcOmp<br />
**[[3jty]] – Omp – ''Pseudomonas fluorescens''<br />
**[[3jty]] – Omp – ''Pseudomonas fluorescens''<br />
**[[2v9u]] – MsOmp rim domain – ''Mycobacteria smegmatis''<br />
**[[2v9u]] – MsOmp rim domain – ''Mycobacteria smegmatis''<br />
**[[1uun]] – MsOmp (mutant)<br />
**[[1uun]] – MsOmp (mutant) <br />
**[[2fgr]] - DaOmp32 - ''Delftia acidovorans''<br />
**[[1a0s]], [[1mpr]] - StOmp - ''Salmonella typhimurium''<br />
**[[3nsg]] - StOmpF<br />
**[[2prn]], [[1bh3]], [[3prn]], [[5prn]], [[6prn]], [[7prn]], [[8prn]] – RbOmp (mutant) - ''Rhodopseudomonas blastica''<br />
**[[2prn]], [[1bh3]], [[3prn]], [[5prn]], [[6prn]], [[7prn]], [[8prn]] – RbOmp (mutant) - ''Rhodopseudomonas blastica''<br />
**[[1prn]] - RbOmp<br />
**[[1prn]] RbOmp<br />
**[[1osm]] – OmpK36 – ''Klebsiella pneumoniae''<br />
**[[1h6s]] – RbOmp+inserted sequence<br />
**[[2por]], [[3por]] – Omp – ''Rhodobacter capsulatus''<br />
**[[2por]], [[3por]] – Omp – ''Rhodobacter capsulatus''<br />
**[[4aui]] – Omp – ''Neisseria gonorrheae''<br />
**[[4aui]] – Omp – ''Neisseria gonorrheae''<br />
**[[4gey]], [[4gf4]] – Omp B – ''Pseudomonas putida''<br />
**[[4fqe]] – DdOmp KDGM – ''Dickeya dadantii''<br />
**[[4fqe]] – DdOmp KDGM – ''Dickeya dadantii''<br />
**[[4pr7]] – DdOmp KDGM + oligogalactouronate<br />


*Porin + polypeptides
*Sugar-specific porin
 
**[[2j4u]] - EcOmpC + lactotransferrin fragment<br />
**[[2zld]] - EcOmpF + colicin E3<br />
**[[3o0e]] - EcOmpF + colicin peptide<br />
**[[1h6s]] - RbOmp + inserted sequence
 
*Porin + various compounds


**[[3hw9]], [[3hwb]] - EcOmpF + ions <br />
**[[1a0s]] – StOmp<br />
**[[3fyx]] - Ec~OmpF + dibenzo-18-crown-6<br />
**[[1oh2]], [[1a0t]] StOmp+sucrose<br />
**[[4gcp]], [[4gcq]], [[4gcs]] – EcOmpF + antibiotic<br />
**[[1af6]], [[1mpq]], [[1mpm]], [[1mpn]], [[1mpo]] - EcOmp LAMB + sugars<br />
**[[3a2s]], [[3a2t]] - NmOmpB + sugars<br />
**[[3a2u]] - NmOmpB + AMPPNP<br />
**[[2o4v]] - PaOprP + phosphate<br />
**[[2fgq]] - DaOmp32 + malate<br />
**[[1e54]] - Omp32 + sulfate - ''Comamonas acidovorans''<br />
**[[1oh2]], [[1a0t]] - StOmp + sucrose<br />
**[[4kr4]], [[4kr8]], [[4kra]] – StOmpF + antibiotics<br />
**[[4pr7]] – DdOmp KDGM + oligogalactouronate<br />


*Maltoporin  
*Maltoporin  


**[[1mal]] – EcLamB<br />
**[[1mal]] – EcLamB<br />
**[[2mpr]] – StLamB<br />
**[[1af6]], [[1mpq]], [[1mpm]], [[1mpn]], [[1mpo]] – EcLamB+sugars<br />
**[[2mpr]], [[1mpr]] – StLamB<br />
 
Voltage-Dependent Anion Channel


See [[Ion channels]]


* Voltage-Dependent Anion Channel See [[Ion channels]]
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==References==
==References==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman, Karsten Theis