5cwa: Difference between revisions

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-'''Unreleased structure'''
+==Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound==
+<StructureSection load='5cwa' size='340' side='right' caption='[[5cwa]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-The entry 5cwa is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cwa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CWA FirstGlance]. <br>
-Authors: Johnston, J.M., Bashiri, G., Evans, G.L., Lott, J.S., Baker, E.N.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GA:3-{[(1Z)-1-CARBOXYPROP-1-EN-1-YL]OXY}-2-HYDROXYBENZOIC+ACID'>0GA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_synthase Anthranilate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.27 4.1.3.27] </span></td></tr>
-Description: Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cwa RCSB], [http://www.ebi.ac.uk/pdbsum/5cwa PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Lott, J.S]]
+== Function ==
-[[Category: Evans, G.L]]
+[[http://www.uniprot.org/uniprot/TRPE_MYCTO TRPE_MYCTO]] Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
-[[Category: Johnston, J.M]]
+__TOC__
+</StructureSection>
+[[Category: Anthranilate synthase]]
+[[Category: Baker, E N]]
 [[Category: Bashiri, G]]
-[[Category: Baker, E.N]]
+[[Category: Evans, G L]]
+[[Category: Johnston, J M]]
+[[Category: Lott, J S]]
+[[Category: Inhibitor]]
+[[Category: Lyase]]
+[[Category: Lyase-lyase inhibitor complex]]