5cs9: Difference between revisions

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'''Unreleased structure'''
==The structure of the NK1 fragment of HGF/SF complexed with MES==
 
<StructureSection load='5cs9' size='340' side='right' caption='[[5cs9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
The entry 5cs9 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5cs9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS9 FirstGlance]. <br>
Authors: Sigurdardottir, A.G., Winter, A., Sobkowicz, A., Fragai, M., Chirgadze, D.Y., Ascher, D.B., Blundell, T.L., Gherardi, E.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cs9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs9 PDBsum]</span></td></tr>
Description: The structure of the NK1 fragment of HGF/SF complexed with MES
</table>
[[Category: Unreleased Structures]]
== Disease ==
[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[http://omim.org/entry/608265 608265]]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ascher, D B]]
[[Category: Blundell, T L]]
[[Category: Chirgadze, D Y]]
[[Category: Fragai, M]]
[[Category: Gherardi, E]]
[[Category: Gherardi, E]]
[[Category: Chirgadze, D.Y]]
[[Category: Sigurdardottir, A G]]
[[Category: Fragai, M]]
[[Category: Sigurdardottir, A.G]]
[[Category: Blundell, T.L]]
[[Category: Ascher, D.B]]
[[Category: Sobkowicz, A]]
[[Category: Sobkowicz, A]]
[[Category: Winter, A]]
[[Category: Winter, A]]
[[Category: Cell cycle]]
[[Category: Fragment based drug discovery]]
[[Category: Growth factor]]
[[Category: Hgf/sf]]
[[Category: Hormone]]
[[Category: New chemical entity]]
[[Category: Nk1 fragment]]

Revision as of 17:56, 12 August 2015

The structure of the NK1 fragment of HGF/SF complexed with MESThe structure of the NK1 fragment of HGF/SF complexed with MES

Structural highlights

5cs9 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.[1]

Function

[HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.[2] [3]

References

  1. ↑ Schultz JM, Khan SN, Ahmed ZM, Riazuddin S, Waryah AM, Chhatre D, Starost MF, Ploplis B, Buckley S, Velasquez D, Kabra M, Lee K, Hassan MJ, Ali G, Ansar M, Ghosh M, Wilcox ER, Ahmad W, Merlino G, Leal SM, Riazuddin S, Friedman TB, Morell RJ. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. Am J Hum Genet. 2009 Jul;85(1):25-39. doi: 10.1016/j.ajhg.2009.06.003. Epub 2009 , Jul 2. PMID:19576567 doi:10.1016/j.ajhg.2009.06.003
  2. ↑ Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J. 2004 Jun 16;23(12):2325-35. Epub 2004 May 27. PMID:15167892 doi:10.1038/sj.emboj.7600243
  3. ↑ Tolbert WD, Daugherty-Holtrop J, Gherardi E, Vande Woude G, Xu HE. Structural basis for agonism and antagonism of hepatocyte growth factor. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13264-9. Epub 2010 Jul 12. PMID:20624990 doi:10.1073/pnas.1005183107

5cs9, resolution 2.00Å

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