4zpr: Difference between revisions

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-'''Unreleased structure'''
+==Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA==
+<StructureSection load='4zpr' size='340' side='right' caption='[[4zpr]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
-The entry 4zpr is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zpr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPR FirstGlance]. <br>
-Authors: Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zp4|4zp4]], [[4zph|4zph]], [[4zpk|4zpk]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zpr RCSB], [http://www.ebi.ac.uk/pdbsum/4zpr PDBsum]</span></td></tr>
-Description: Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). [[http://www.uniprot.org/uniprot/HIF1A_MOUSE HIF1A_MOUSE]] Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Kim, Y]]
+[[Category: Lu, J]]
 [[Category: Potluri, N]]
-[[Category: Lu, J]]
 [[Category: Rastinejad, F]]
 [[Category: Wu, D]]
-[[Category: Kim, Y]]
+[[Category: Arnt]]
+[[Category: Bhlh-pa]]
+[[Category: Hif-1a]]
+[[Category: Hre]]
+[[Category: Protein transport-transcription-dna complex]]