SCF-KIT: Difference between revisions
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<StructureSection load='2ZW3' size='340' side='right' caption='Caption for this structure' scene='> | |||
== Introduction == | == Introduction == | ||
'''Stem cell factor (SCF)''' is a cytokine that mediates its diverse cellular responses by binding to and activating the [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase (RTK)] [https://en.wikipedia.org/wiki/CD117 KIT] (also known as SCF receptor). [https://en.wikipedia.org/wiki/Stem_cell_factor SCF] functions as a noncovalent homodimer, and both membrane-anchored and soluble forms of SCF have been described. | '''Stem cell factor (SCF)''' is a cytokine that mediates its diverse cellular responses by binding to and activating the [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase (RTK)] [https://en.wikipedia.org/wiki/CD117 KIT] (also known as SCF receptor). [https://en.wikipedia.org/wiki/Stem_cell_factor SCF] functions as a noncovalent homodimer, and both membrane-anchored and soluble forms of SCF have been described. | ||
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== Structure == | == Structure == | ||
The two sets of KIT ectodomains and SCF molecules resemble an upside down ‘‘A’’ letter and the entire ectodomain of KIT is composed of five Ig-like domains: D1-D5. | The two sets of KIT ectodomains and SCF molecules resemble an upside down ‘‘A’’ letter and the entire ectodomain of KIT is composed of five Ig-like domains: D1-D5. SCF dimer interacts symmetrically with D1, D2, and D3 of two corresponding KIT ectodomains. In addition, KIT ectodomains form homophylic interactions through lateral contacts between D4 and D5 of the two neighboring receptors. The folding of the 5 KIT domains is a typical folding to the immunoglobulin super family. | ||
'''Structural changes upon SCF binding to KIT:''' | '''Structural changes upon SCF binding to KIT:''' | ||
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== References == | == References == | ||
* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836632/pdf/pnas.0914052107.pdf ''Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling'']. Schlessinger j., et al. (2009). PNAS 107(5):1906-1911. | * [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836632/pdf/pnas.0914052107.pdf ''Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling'']. Schlessinger j., et al. (2009). PNAS 107(5):1906-1911. | ||
* [http://ac.els-cdn.com/S0092867407007593/1-s2.0-S0092867407007593-main.pdf?_tid=3f2b8724-02c9-11e5-8dd1-00000aacb360&acdnat=1432550087_b8500d0b937413eeac56902fe4b8f15f ''Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor'']. Schlessinger j., et al. (2007). Cell 130(2):323-34. | * [http://ac.els-cdn.com/S0092867407007593/1-s2.0-S0092867407007593-main.pdf?_tid=3f2b8724-02c9-11e5-8dd1-00000aacb360&acdnat=1432550087_b8500d0b937413eeac56902fe4b8f15f ''Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor'']. Schlessinger j., et al. (2007). Cell 130(2):323-34. | ||