4ywc: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of Myc3(5-242) fragment in complex with Jaz9(218-239) peptide==
 
<StructureSection load='4ywc' size='340' side='right' caption='[[4ywc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
The entry 4ywc is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ywc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWC FirstGlance]. <br>
Authors: Ke, J., Zhang, F., Brunzelle, J.S., Xu, H.E., Melcher, K., He, S.Y.
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rru|4rru]], [[4rqw|4rqw]], [[4rs9|4rs9]]</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ywc RCSB], [http://www.ebi.ac.uk/pdbsum/4ywc PDBsum]</span></td></tr>
Description:  
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Xu, H.E]]
[[http://www.uniprot.org/uniprot/MYC3_ARATH MYC3_ARATH]] Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters.<ref>PMID:12136026</ref> <ref>PMID:21242320</ref> <ref>PMID:21321051</ref> <ref>PMID:21335373</ref> <ref>PMID:23943862</ref>  [[http://www.uniprot.org/uniprot/TIF7_ARATH TIF7_ARATH]] Repressor of jasmonate responses negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-protein ligase complex-dependent manner. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY7/JAZ9 interaction.<ref>PMID:19151223</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Brunzelle, J S]]
[[Category: He, S Y]]
[[Category: Ke, J]]
[[Category: Melcher, K]]
[[Category: Melcher, K]]
[[Category: He, S.Y]]
[[Category: Xu, H E]]
[[Category: Brunzelle, J.S]]
[[Category: Zhang, F]]
[[Category: Zhang, F]]
[[Category: Ke, J]]
[[Category: Helix-sheet-helix sandwich fold]]
[[Category: Jasmonate signaling]]
[[Category: Myc transcription factor]]
[[Category: Myc-jaz complex]]
[[Category: Transcription regulator]]

Revision as of 23:15, 5 August 2015

Crystal structure of Myc3(5-242) fragment in complex with Jaz9(218-239) peptideCrystal structure of Myc3(5-242) fragment in complex with Jaz9(218-239) peptide

Structural highlights

4ywc is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[MYC3_ARATH] Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters.[1] [2] [3] [4] [5] [TIF7_ARATH] Repressor of jasmonate responses negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-protein ligase complex-dependent manner. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY7/JAZ9 interaction.[6]

References

  1. ↑ Smolen GA, Pawlowski L, Wilensky SE, Bender J. Dominant alleles of the basic helix-loop-helix transcription factor ATR2 activate stress-responsive genes in Arabidopsis. Genetics. 2002 Jul;161(3):1235-46. PMID:12136026
  2. ↑ Cheng Z, Sun L, Qi T, Zhang B, Peng W, Liu Y, Xie D. The bHLH transcription factor MYC3 interacts with the Jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis. Mol Plant. 2011 Mar;4(2):279-88. doi: 10.1093/mp/ssq073. Epub 2011 Jan 17. PMID:21242320 doi:http://dx.doi.org/10.1093/mp/ssq073
  3. ↑ Niu Y, Figueroa P, Browse J. Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis. J Exp Bot. 2011 Mar;62(6):2143-54. doi: 10.1093/jxb/erq408. Epub 2011 Feb 14. PMID:21321051 doi:http://dx.doi.org/10.1093/jxb/erq408
  4. ↑ Fernandez-Calvo P, Chini A, Fernandez-Barbero G, Chico JM, Gimenez-Ibanez S, Geerinck J, Eeckhout D, Schweizer F, Godoy M, Franco-Zorrilla JM, Pauwels L, Witters E, Puga MI, Paz-Ares J, Goossens A, Reymond P, De Jaeger G, Solano R. The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. Plant Cell. 2011 Feb;23(2):701-15. doi: 10.1105/tpc.110.080788. Epub 2011 Feb 18. PMID:21335373 doi:http://dx.doi.org/10.1105/tpc.110.080788
  5. ↑ Schweizer F, Fernandez-Calvo P, Zander M, Diez-Diaz M, Fonseca S, Glauser G, Lewsey MG, Ecker JR, Solano R, Reymond P. Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior. Plant Cell. 2013 Aug;25(8):3117-32. doi: 10.1105/tpc.113.115139. Epub 2013 Aug, 13. PMID:23943862 doi:http://dx.doi.org/10.1105/tpc.113.115139
  6. ↑ Chung HS, Howe GA. A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis. Plant Cell. 2009 Jan;21(1):131-45. doi: 10.1105/tpc.108.064097. Epub 2009 Jan 16. PMID:19151223 doi:http://dx.doi.org/10.1105/tpc.108.064097

4ywc, resolution 2.40Å

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