4owp: Difference between revisions

Revision as of 23:08, 5 August 2015

Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.

Structural highlights

4owp is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	4o8x, 4o8y
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[RPN8_YEAST] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.^[1] [RPN11_YEAST] Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.^[2]

References

↑ Glickman MH, Rubin DM, Fried VA, Finley D. The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol. 1998 Jun;18(6):3149-62. PMID:9584156
↑ Chen L, Romero L, Chuang SM, Tournier V, Joshi KK, Lee JA, Kovvali G, Madura K. Sts1 plays a key role in targeting proteasomes to the nucleus. J Biol Chem. 2011 Jan 28;286(4):3104-18. doi: 10.1074/jbc.M110.135863. Epub 2010 , Nov 12. PMID:21075847 doi:10.1074/jbc.M110.135863

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OCA

[1] Glickman MH, Rubin DM, Fried VA, Finley D. The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol. 1998 Jun;18(6):3149-62. PMID:9584156

[2] Chen L, Romero L, Chuang SM, Tournier V, Joshi KK, Lee JA, Kovvali G, Madura K. Sts1 plays a key role in targeting proteasomes to the nucleus. J Biol Chem. 2011 Jan 28;286(4):3104-18. doi: 10.1074/jbc.M110.135863. Epub 2010 , Nov 12. PMID:21075847 doi:10.1074/jbc.M110.135863

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.==
+<StructureSection load='4owp' size='340' side='right' caption='[[4owp]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-The entry 4owp is ON HOLD  until Aug 03 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4owp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWP FirstGlance]. <br>
-Authors: Yu, Z., Mansour, W., Nakasone, M.A., Glickman, M.H., Dvir, H.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o8x|4o8x]], [[4o8y|4o8y]]</td></tr>
-Description: Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owp RCSB], [http://www.ebi.ac.uk/pdbsum/4owp PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Yu, Z]]
+== Function ==
+[[http://www.uniprot.org/uniprot/RPN8_YEAST RPN8_YEAST]] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:9584156</ref>  [[http://www.uniprot.org/uniprot/RPN11_YEAST RPN11_YEAST]] Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.<ref>PMID:21075847</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Dvir, H]]
-[[Category: Glickman, M.H]]
+[[Category: Glickman, M H]]
-[[Category: Nakasone, M.A]]
 [[Category: Mansour, W]]
+[[Category: Nakasone, M A]]
+[[Category: Yu, Z]]
+[[Category: Deubiquitination]]
+[[Category: Hydrolase]]
+[[Category: Metalloprotease]]
+[[Category: Mpn domain]]
+[[Category: Proteosome]]
+[[Category: Ubiquitin]]
+[[Category: Zinc]]

4owp: Difference between revisions

Revision as of 23:08, 5 August 2015

Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.

Structural highlights

Function

References

Contents

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4owp: Difference between revisions

Revision as of 23:08, 5 August 2015

Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.

Structural highlights

Function

References

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