Connexin: Difference between revisions

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Doaa Naffaa, Safaa Salah Hussiesy, Michal Harel, Jaime Prilusky

Revision as of 15:08, 25 July 2015 view source Safaa Salah Hussiesy (talk \| contribs) 177 edits No edit summary ← Older edit		Revision as of 15:08, 25 July 2015 view source Safaa Salah Hussiesy (talk \| contribs) 177 edits No edit summary Newer edit →
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	==How does connexin 26 work ~~biochemically~~?==		==How does connexin 26 biochemically work?==
	Connexin 26 (CX26) protein is essential for maintaining the high K+ concentration in the [http://en.wikipedia.org/wiki/Endolymph endolymph] of the inner ear. Sound stimulation of the ossicular chain causes vibrations in the [http://en.wikipedia.org/wiki/Endolymph endolymph] .K+ ions enter the hair cells under the influence of these vibrations and vibration signal is ultimately converted into a neural signal. The system is regenerated by the release of K+ from the hair cells into the supporting cells. The K+ ions are then passed from cell to cell via gap junctions and are eventually released into the endolymph. Except for sensorineural cells, the CX26 protein is present in gap junctions connecting all cell types in the [http://en.wikipedia.org/wiki/Cochlea cochlea], including the spiral limbus, the supporting cells, the spiral ligament and the basal and intermediate cells of the [http://en.wikipedia.org/wiki/Stria_vascularis_of_cochlear_duct stria vascularis]. It is therefore very likely that connexin 26 is involved in K+ recycling in the [http://en.wikipedia.org/wiki/Cochlea cochlea].<ref name='function'>pmid 11810458</ref>		Connexin 26 (CX26) protein is essential for maintaining the high K+ concentration in the [http://en.wikipedia.org/wiki/Endolymph endolymph] of the inner ear. Sound stimulation of the ossicular chain causes vibrations in the [http://en.wikipedia.org/wiki/Endolymph endolymph] .K+ ions enter the hair cells under the influence of these vibrations and vibration signal is ultimately converted into a neural signal. The system is regenerated by the release of K+ from the hair cells into the supporting cells. The K+ ions are then passed from cell to cell via gap junctions and are eventually released into the endolymph. Except for sensorineural cells, the CX26 protein is present in gap junctions connecting all cell types in the [http://en.wikipedia.org/wiki/Cochlea cochlea], including the spiral limbus, the supporting cells, the spiral ligament and the basal and intermediate cells of the [http://en.wikipedia.org/wiki/Stria_vascularis_of_cochlear_duct stria vascularis]. It is therefore very likely that connexin 26 is involved in K+ recycling in the [http://en.wikipedia.org/wiki/Cochlea cochlea].<ref name='function'>pmid 11810458</ref>